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Hope For Alzheimers Disease
July 27, 2010: 1 comment(s)
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Currently there are no successful treatments for Alzheimer’s Disease, but scientists may have discovered a remarkable compound found in plants that offers new hope. These compounds called polyphenols are found in cocoa (dark chocolate), berries, nuts, wine as well as other fruits and vegetables and may eventually hold the key to the cure.
As a part of a research team at UCLA, David Teplow, professor of neurology, said of their research, “No disease-modifying treatments of Alzheimer’s now exist…so we believe that this is an important next step.”
Alzheimer’s is caused by the buildup of two proteins in the brain, amyloid beta 40 and amyloid beta 42. They build up toxic plaques which kill brain cells. These plaques are the targets of Alzheimer’s research.
Teplow’s team found that when these two proteins bind together, creating aggregates, they destroy mouse nerve cells. Researchers found that when they treated the two proteins with polyphenols (from grape seeds) they could not form aggregates and the toxicity of previously formed aggregates was reduced.
“What we found is pretty straightforward. If the amyloid beta proteins can’t assemble, toxic aggregates can’t form, and thus there is no toxicity. Our work in the laboratory, and Mt. Sinai’s Dr. Giulio Pasinetti’s work in mice, suggest that administration of the compound to Alzheimer’s patients might block the development of these toxic aggregates, prevent disease development and also ameliorate existing disease.”
There are over 8,000 polyphenols, all found in a healthy plant-based diet.
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Comments (Scroll to the end to leave a comment)
Carol-Sue
07/28/10 04:14
Great article; how wonderful it would be if the polyphenols prove to really work at the human level in preventing Alzheimer's! There really is a lot of potential for preventing all sorts of ailments with polyphenols, along with phytochemicals.
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